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The final Culture Show of the current series comes from the Whitechapel Art Gallery in east London. It is presented by Lauren Laverne, Andrew Graham-Dixon and Mark Kermode.

Find out what happens when a prominent figure in British politics meets his fictional nemesis. Alastair Campbell reviews Armando Iannucci's first feature film In the Loop, which features spin doctor Malcolm Tucker and his role in Britain's involvement in a controversial war.

After a 13-million-pound restoration, the Whitechapel re-opens in April 2009. Andrew Graham-Dixon tells the story of the gallery that transformed the British art scene. He also reviews the opening exhibitions, including a new installation by Goshka Macuga, which features Picasso's Guernica tapestry on loan from the UN in New York.

Mark Kermode has a rare interview with a cinematic one-off - the playwright, screenplay writer and now film director Charlie Kaufman. The writer of Being John Malkovich and Eternal Sunshine of the Spotless Mind has made his first film as director, Synecdoche New York, starring Philip Seymour Hoffman.

Lauren Laverne has an equally rare interview with American singer-songwriter Will Oldham, who also goes by the name Bonnie 'Prince' Billy. His concerts sell out within minutes, and music critics call him a wayward genius and the finest songwriter to come out of America for years. Exclusively for the Culture Show, Bonnie 'Prince' Billy performs a stripped-down version of You Can't Hurt Me Now from his new album.