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MP's join Shelagh to discuss the shooting dead of two WPC's in Greater Manchester as it emerges a man being questioned had been released on bail in connection with another murder. Thousands of tributes have poured in for Fiona Bone and Nicola Hughes who were killed in a gun and grenade attack. PC Hughes family and friends said she'd died doing the job that she loved.

Also are the world's leading pharmaceutical companies giving up on the search for a cure for Alzheimer's disease? There's reports today suggesting failures in a series of high-profile drugs trials has damaged manufacturers' confidence in the field of neuroscience. The trial of one drug is said to have cost one company 750 million dollars in lost investment. Another firm is said to be reducing its neuroscience team from three-hundred scientists to forty. Shelagh speaks to the Alzheimers Society.