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Psychedelic drugs are once again being trialled to treat a range of psychological conditions. The writer Mike Pollan tells Kirsty Wark about the science of LSD and magic mushrooms: from the 1940s to the 1960s they promised to shed light not only on the deep mysteries of consciousness, but also to offer relief from addiction and mental illness. Banned since the 1970s, there is now a resurgence of research into these mind-altering substances.

While some psychiatrists were getting their patients to experiment with psychedelics in the 1950s, far more were administering electroconvulsive therapy - both have a controversial history. ECT involves sending an electric current through the brain to trigger an epileptic seizure. It gained a reputation as a barbaric treatment, after the film One Flew Over The Cuckoo's Nest. But the psychiatrist Dr Tammy Burmeister believes that it's time people understood the therapeutic potential from this procedure.

The poet Andrew Motion's latest book Essex Clay is an attempt to return to heartfelt memories of childhood. He looks back at his mother's riding accident, which left her 'floating herself among the nebulae and gas clouds of her vast unconsciousness' and her subsequent slow death. The book revolves around loss and memory and retrieval.

The evolution of the human brain is one of the wonders of nature, but the philosopher of science Peter Godfrey-Smith asks what if intelligent life on Earth evolved not once, but twice? He wonders how the octopus - a solitary creature - became so smart. He traces the story from single-celled organism 3.8 billion years ago to the development of cephalopod consciousness, casting new light on the octopus mind.

Producer: Katy Hickman.