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A calf born with an extraordinarily rare condition is brought in to see vet Martin Fitzpatrick at Castle Vets.

Castle Vets also run an obesity clinic, and head nurse Julie Hurst has an appointment with seven-year-old cat Paws, whose weight has been steadily increasing over the last few years. Paws suffered a traumatic road accident in which she lost a leg, and getting her weight down is crucial. Owners Amanda and Martin are given strict instructions but will they follow Julie鈥檚 advice?

Vet Aidan O'Hare heads out to see Limousin bull Navarn, who has mysteriously gone lame. It is a blow to his owners, the McPolins, who earn their living raising and selling pedigree breeding bulls. If Navarn can't be successfully treated, he will have be sold for meat at a serious loss to his owners.

At the stud at Tullyraine Equine Clinic, breeder John has booked in his mare Sweetbriar Rose to mate with stallion Conduit in the hope of producing a prize racehorse. Sweetbriar Rose is 'teased' by a male pony to get her ready to mate with Conduit and the mating goes well, but will it result in a pregnancy?

At the clinic in Downpatrick, two superstar northern inuit hounds from Game of Thrones are brought in to see Maurice. One of them has painful sores on his paws.

Two-year-old labrador Cooper is next to be seen. His owners, the Flanagans, are very worried about him after finding blood in his urine. Vet Daisy Dillon keeps him in for tests, and it soon becomes clear that Cooper's blood count is dangerously low. Over the next few days, the entire team at Downe Vets are involved in Cooper's treatment in a bid to save his life.