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As Donald Trump secures the Republican presidential nomination, we ask how much of his popularity is being driven by economics and trade rather than race and immigration, as many assume. Fergus Nicoll reports from Cleveland, a city that's had to re-invent itself as a centre for cutting edge biomedical research, while old factory jobs are becoming a distant memory as manufacturing moves to cheaper locations overseas. Also, David Wessel, director at the the Hutchins Centre on Fiscal and Monetary Policy at the Brookings Institution in Washington, explains how the hollowing out of jobs in the manufacturing sector has created a base of support for Donald Trump among blue-collar workers. And Jane O'Brien reports from Winchester, Virginia, on what small business owners hope the US presidential elections will deliver for them.

(Picture: An industrial area in Cleveland, Ohio; Credit: Brendan Smialowski/AFP/Getty Images)